I'm not sure whether the tentacled alien in the new Futurama movie, The Beast with a Billion Backs, actually qualifies as Lovecraft-inspired. It sounds quite Futuramic, and David X. Cohen's comments that the alien has "romantic interests" in every "single living being in our universe" sounds a bit hentai -- like it'll strip away your clothes rather than your sanity. Still, there was a Yithian in the Futurama episode A Bicyclops Built For Two, so maybe Matt Groening has a touch of Lovecraft in him.
(Image has nothing to do with Futurama. I found it via a Google search for 'tentacle monster' -- it was one of the few images that didn't have appendages squidging their way into girls' bits)
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